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Dr. Uwe Niedermeyer and Prof. Dr. Maria-Regina Kula Enzyme-Catalyzed Synthesis of (S)-Cyanohydrins Angewandte Chemie International Edition in English 29

Version of Record online: 22 DEC 2003 | DOI: 10.1002/anie.199003861

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An oxynitrilase from Sorghum bicolor is a highly stereoselective catalyst for the addition of hydrogen cyanide to homocyclic aromatic aldehydes, leading to (S)-cyanohydrins. Reaction in aqueous medium results in ee-values as high as 99%. Reactions with this catalyst can be carried out in a continuous fashion.

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