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Prof. Dr. K. C. Nicolaou and Dr. W.-M. Dai Chemistry and Biology of the Enediyne Anticancer Antibiotics Angewandte Chemie International Edition in English 30

Article first published online: 22 DEC 2003 | DOI: 10.1002/anie.199113873

Hardly four years old and yet far enough advanced for a fascinating review is the area of enediyne anticancer antibiotics. The unique molecular structure and impressive biological effects of these compounds have started a broad movement, inspiring new research in computer-supported chemistry, molecular design, the chemistry of DNA, and medicine. This review article focuses on the syntheses and the chemical and biological properties of model systems based on the natural enediyne antibiotics neocarzinostatin chromophore, the calicheamicins, esperamicins, and dynemicins.

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