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Priv.-Doz. Dr. Athanassios Giannis and Dr. Thomas Kolter Peptidomimetics for Receptor Ligands—Discovery, Development, and Medical Perspectives Angewandte Chemie International Edition in English 32

Version of Record online: 22 DEC 2003 | DOI: 10.1002/anie.199312441

Increased metabolic stability, better bioavailability, and longer duration of action characterize peptidomimetics, compounds that can replace native peptides in their interaction with receptors. Peptidomimetics can be used as aids in the investigation of peptidergic systems and also as therapeutic agents. Until recently their design has been predominantly empirical (modification of native peptides, optimization of lead structures), but a rational design based on studies of structure and conformation energies is gradually gaining support.

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