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Prof. Dr. Kyriacos Costa Nicolaou The Total Synthesis of Brevetoxin B: A Twelve-Year Odyssey in Organic Synthesis Angewandte Chemie International Edition in English 35

Version of Record online: 22 DEC 2003 | DOI: 10.1002/anie.199605881

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What is the connection between the total synthesis of brevetoxin and the 1994 Soccer World Cup? Apparently irrelevant factors have extensive ramifications for natural product syntheses. The marine biotoxin brevetoxin B, which is responsible for mass poisoning of humans and marine life during “red tides”, was the target of an intense research program in the Nicolaou group. Their perseverance paid off with a wealth of new reactions as dividends. In this “story behind the story” the author describes both the successes and failures along the way.

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