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Prof. Dr. K. C. Nicolaou, Dr. Floris van Delft, Dr. Takashi Ohshima, Dr. Dionisios Vourloumis, Dr. Jinyou Xu, Dr. Seijiro Hosokawa, Jeffrey Pfefferkorn, Dr. Sanghee Kim and Dr. Tianhu Li Total Synthesis of Eleutherobin Angewandte Chemie International Edition in English 36

Version of Record online: 22 DEC 2003 | DOI: 10.1002/anie.199725201

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Taxol-like activity is exhibited by eleutherobin (1), one of the most promising antitumor agents isolated from nature in recent years. The first total synthesis of this compound also provided a route to two biologically active analogues, thus enabling the first structure–activity relationships within the eleutherobin family to be established.

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