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Lutz F. Tietze, Hubertus P. Bell and Srivari Chandrasekhar Natural Product Hybrids as New Leads for Drug Discovery Angewandte Chemie International Edition 42

Version of Record online: 5 SEP 2003 | DOI: 10.1002/anie.200200553

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Unlimited options: The synthesis of natural product hybrids by combining structurally different, naturally occurring compounds that exhibit high biological activities appears to be a promising approach to increase the number and diversity of substances for pharmacological testing. An example is the hybrid of estrone and (−)-talaromycin (see picture).

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