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Michael Breuer, Klaus Ditrich, Tilo Habicher, Bernhard Hauer, Maria Keßeler, Rainer Stürmer and Thomas Zelinski Industrial Methods for the Production of Optically Active Intermediates Angewandte Chemie International Edition 43

Article first published online: 2 FEB 2004 | DOI: 10.1002/anie.200300599

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Of fundamental importance for the pharmaceutical industry is the large-scale availability of enantiomerically pure intermediates, such as amino acids, amino alcohols, amines, alcohols, and epoxides. In this Review industrially relevant syntheses of such intermediates are presented, based on chemical as well as enzymatic and fermentation processes (see scheme).

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