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Daniel G. Anderson, David M. Lynn and Robert Langer Semi-Automated Synthesis and Screening of a Large Library of Degradable Cationic Polymers for Gene Delivery Angewandte Chemie International Edition 42

Version of Record online: 10 JUL 2003 | DOI: 10.1002/anie.200351244

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Higher delivery efficiency than conventional nonviral systems (such as poly(ethyleneimine)) have been identified in 46 polymers through cell-based screening of a large, 2350-member library by a high-throughput, semi-automated process. The transfection potential of the polymers was assessed by testing their ability to deliver luciferase expressing plasmid and green fluorescent protein plasmid (see picture) to a monkey kidney fibroblast cell line.

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