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Duhee Bang and Stephen B. H. Kent A One-Pot Total Synthesis of Crambin Angewandte Chemie International Edition 43

Version of Record online: 28 APR 2004 | DOI: 10.1002/anie.200353540

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Making up for lost time: The one-pot synthesis of crambin (see structure) with only a single final purification step gave the target protein of exceptional purity in only two days with an overall yield of ≈40 %. Three unprotected peptide segments were linked by native chemical ligation, and the polypeptide chain assumed its 3D structure without intermediate purification steps.

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