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Jörg Eppinger, Daniel P. Funeriu, Masato Miyake, Lucile Denizot and Jun Miyake Enzyme Microarrays: On-Chip Determination of Inhibition Constants Based on Affinity-Label Detection of Enzymatic Activity Angewandte Chemie International Edition 43

Version of Record online: 12 JUL 2004 | DOI: 10.1002/anie.200353623

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High-throughput screening of libraries of potential inhibitors is possible by using an enzyme microarray method that combines low sample consumption with accuracy and speed. Information about enzyme inhibition can be obtained “on-chip” by the addition of a fluorescently tagged affinity label to a microarray of functional enzymes (see picture).

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