Teodoro S. Kaufman and Edmundo A. Rúveda The Quest for Quinine: Those Who Won the Battles and Those Who Won the War Angewandte Chemie International Edition 44
Tonic for the troops: The year 2004 marks the 60th anniversary of Woodward's total synthesis of quinine (see picture), which for a long time had been the only useful treatment for malaria. Quinine proved to be an attractive and elusive synthetic target since Perkin's attempts in 1856, which gave birth to industrial organic synthesis and the dye industry. This Review highlights the history of the isolation, structural elucidation, and synthesis of quinine.
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