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Davide Pantarotto, Ravi Singh, David McCarthy, Mathieu Erhardt, Jean-Paul Briand, Maurizio Prato, Kostas Kostarelos and Alberto Bianco Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery Angewandte Chemie International Edition 43

Article first published online: 29 SEP 2004 | DOI: 10.1002/anie.200460437

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Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA–nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.

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