Valentin O. Rodionov, Valery V. Fokin and M. G. Finn Mechanism of the Ligand-Free CuI-Catalyzed Azide–Alkyne Cycloaddition Reaction Angewandte Chemie International Edition 44
A powerful engine: The Cu-catalyzed azide–alkyne cycloaddition depends on rapid formation of CuI–acetylide complexes from terminal alkynes 2 and their ability to activate organic azides 1. A kinetics study uncovered a bimolecular dependence on the metal and an unusually fast intramolecular variant of the process. The results suggest the importance of 3 as a reactive intermediate.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf