Tehshik P. Yoon and Eric N. Jacobsen Highly Enantioselective Thiourea-Catalyzed Nitro-Mannich Reactions Angewandte Chemie International Edition 44
Approaching “privileged” status? A new and highly effective enantioselective catalyst for the nitro-Mannich reaction was identified by modification of thiourea-based Strecker catalysts (see scheme). Products are obtained in high enantiomeric purity and up to 16:1 diastereoselectivity.
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