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Gérard Klein, Nicolas Humbert, Julieta Gradinaru, Anita Ivanova, François Gilardoni, Untung E. Rusbandi and Thomas R. Ward Tailoring the Active Site of Chemzymes by Using a Chemogenetic-Optimization Procedure: Towards Substrate-Specific Artificial Hydrogenases Based on the Biotin–Avidin Technology Angewandte Chemie International Edition 44

Article first published online: 8 NOV 2005 | DOI: 10.1002/anie.200502000

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The combination of chemical- with genetic-optimization strategies (i.e. chemogenetic) allows the production of artificial hydrogenases based on the biotin–avidin technology. In the spirit of enzymes, second-coordination-sphere interactions between the host protein (streptavidin) and the substrate (an olefin) allow fine-tuning of the selectivity to produce either R or S hydrogenation products.

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