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Susan E. Gibson and Cristina Lecci Amino Acid Derived Macrocycles—An Area Driven by Synthesis or Application? Angewandte Chemie International Edition 45

Version of Record online: 30 JAN 2006 | DOI: 10.1002/anie.200503428

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A vancomycin mimic: Synthetic macrocycle 1 shows promising antibiotic activity towards Gram-positive bacterial strands owing to its ability to bind the (R)-alanyl-(R)-alanine terminus of peptoglycans. But how useful are other amino acid derived macrocycles?

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