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Thomas Purkarthofer, Karl Gruber, Mandana Gruber-Khadjawi, Kerstin Waich, Wolfgang Skranc, Daniel Mink and Herfried Griengl A Biocatalytic Henry Reaction—The Hydroxynitrile Lyase from Hevea brasiliensis Also Catalyzes Nitroaldol Reactions Angewandte Chemie International Edition 45

Version of Record online: 24 APR 2006 | DOI: 10.1002/anie.200504230

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Novel enzyme activity: Biocatalytic Henry reactions with nitromethane and nitroethane yielded the corresponding nitroalcohols with good enantio- and diastereocontrol in the presence of the hydroxynitrile lyase from the tropical rubber tree Hevea brasiliensis. Molecular modeling and deuterated starting materials were used in mechanistic investigations.

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