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Hai Yu, Shengshu Huang, Harshal Chokhawala, Mingchi Sun, Haojie Zheng and Xi Chen Highly Efficient Chemoenzymatic Synthesis of Naturally Occurring and Non-Natural α-2,6-Linked Sialosides: A P. damsela α-2,6-Sialyltransferase with Extremely Flexible Donor–Substrate Specificity Angewandte Chemie International Edition 45

Version of Record online: 24 MAY 2006 | DOI: 10.1002/anie.200600572

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Just relax: A one-pot, three-enzyme chemoenzymatic synthetic approach is highly efficient for obtaining complex sialosides that contain diverse naturally occurring sialic acid modifications. α-2,6-Linked sialosides containing twelve naturally occurring sialic acid forms and seven non-natural sialic acid forms have been obtained.

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