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Bruce H. Lipshutz and Benjamin R. Taft Heterogeneous Copper-in-Charcoal-Catalyzed Click Chemistry Angewandte Chemie International Edition 45

Version of Record online: 17 NOV 2006 | DOI: 10.1002/anie.200603726

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Click here for Cu/C: Copper-in-charcoal (Cu/C) is an active catalyst for effecting click reactions between organic azides and 1-alkynes. Rates of cycloaddition are increased dramatically when carried out in the presence of Et3N or using microwave assistance. There is no sensitivity to air or moisture, and the catalyst can be recycled several times without loss of activity or selectivity for the 1,4-adduct.

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