E-mail

E-mail a Wiley Online Library Link

Johannes Steinreiber, Martin Schürmann, Michael Wolberg, Friso van Assema, Christoph Reisinger, Kateryna Fesko, Daniel Mink and Herfried Griengl Overcoming Thermodynamic and Kinetic Limitations of Aldolase-Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations Angewandte Chemie International Edition 46

Version of Record online: 24 JAN 2007 | DOI: 10.1002/anie.200604142

Thumbnail image of graphical abstract

Dynamic and successful: The asymmetric synthesis of 2-amino-1-phenylethanol was achieved by aminomethylation of benzaldehyde in the presence of the two enzymes L-threonine aldolase and L-tyrosine decarboxylase in a novel one-pot, two-enzyme process (see scheme). A modified method with three enzymes led to the enantioenriched amino alcohol in very high yield.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH