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Johannes Steinreiber, Martin Schürmann, Michael Wolberg, Friso van Assema, Christoph Reisinger, Kateryna Fesko, Daniel Mink and Herfried Griengl Overcoming Thermodynamic and Kinetic Limitations of Aldolase-Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations Angewandte Chemie International Edition 46

Version of Record online: 24 JAN 2007 | DOI: 10.1002/anie.200604142

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Dynamic and successful: The asymmetric synthesis of 2-amino-1-phenylethanol was achieved by aminomethylation of benzaldehyde in the presence of the two enzymes L-threonine aldolase and L-tyrosine decarboxylase in a novel one-pot, two-enzyme process (see scheme). A modified method with three enzymes led to the enantioenriched amino alcohol in very high yield.

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