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Miguel D. Toscano, Kenneth J. Woycechowsky and Donald Hilvert Minimalist Active-Site Redesign: Teaching Old Enzymes New Tricks Angewandte Chemie International Edition 46

Version of Record online: 23 APR 2007 | DOI: 10.1002/anie.200604205

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Reduce, reuse, recycle: Enzymes catalyze a wide variety of chemical reactions. However, suitable enzymatic catalysts are lacking for many useful transformations. New catalytic activities arise from mutations in the active site, suggesting that the pool of existing enzymes can be a promising starting point for the creation of catalysts for nonbiological reactions. Often, a single point mutation is sufficient to endow an enzyme with a new function.

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