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Zhuang Liu, Mark Winters, Mark Holodniy and Hongjie Dai siRNA Delivery into Human T Cells and Primary Cells with Carbon-Nanotube Transporters Angewandte Chemie International Edition 46

Article first published online: 9 FEB 2007 | DOI: 10.1002/anie.200604295

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Special delivery: Functionalized single-walled nanotubes (SWNT) can be used as molecular transporters to shuttle short interfering RNA (siRNA) into human T cells and primary cells and silence the expression of HIV-specific cell-surface receptors and coreceptors (see picture; scale bars 40 μm). This silencing effect, known to block HIV viral entry and reduce infection, is superior to that observed with conventional liposome-based nonviral delivery agents.

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