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Robert P. Gibson, Tracey M. Gloster, Shirley Roberts, R. Anthony J. Warren, Isabel Storch de Gracia, Ángela García, Jose L. Chiara and Gideon J. Davies Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors Angewandte Chemie International Edition 46

Version of Record online: 23 APR 2007 | DOI: 10.1002/anie.200604825

Thumbnail image of graphical abstract

Strong inhibitions: The inhibition of trehalases, enzymes which hydrolyze the disaccharide trehalose, is a target for novel antibiotic insecticides. The structures (see picture; C black, N blue, O red, S yellow) of a trehalase in complex with validoxylamine A (yellow) and 1-thiatetrazolin (blue) reveal that the inhibitors tightly bind to the enzyme through hydrogen bonds.

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