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Elizabeth R. Gillies, Frédérique Deiss, Cathy Staedel, Jean-Marie Schmitter and Ivan Huc Development and Biological Assessment of Fully Water-Soluble Helical Aromatic Amide Foldamers Angewandte Chemie International Edition 46

Article first published online: 19 APR 2007 | DOI: 10.1002/anie.200700301

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Abiotic but bioactive: Folding aromatic amide oligomers possessing helical structures very different from those of α-peptides, β-peptides, or peptoids nevertheless show comparable abilities to penetrate into cells, as well as low toxicity and complete resistance to protease degradation. TFA=trifluoroacetate.

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