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Julien Pierron, Christophe Malan, Marc Creus, Julieta Gradinaru, Ines Hafner, Anita Ivanova, Alessia Sardo and Thomas R. Ward Artificial Metalloenzymes for Asymmetric Allylic Alkylation on the Basis of the Biotin–Avidin Technology Angewandte Chemie International Edition 47

Article first published online: 8 JAN 2008 | DOI: 10.1002/anie.200703159

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Palladium in the active site: The incorporation of a biotinylated palladium diphosphine within streptavidin yielded an artificial metalloenzyme for the title reaction (see scheme). Chemogenetic optimization of the catalyst by the introduction of a spacer (red star) between biotin (green triangle) and palladium and saturation mutagenesis at position S112X afforded both R- and S-selective artificial asymmetric allylic alkylases.

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