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Abhijit Mishra, Vernita D. Gordon, Lihua Yang, Robert Coridan and Gerard C. L. Wong HIV TAT Forms Pores in Membranes by Inducing Saddle-Splay Curvature: Potential Role of Bidentate Hydrogen Bonding Angewandte Chemie International Edition 47

Article first published online: 12 MAR 2008 | DOI: 10.1002/anie.200704444

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Pore performance: The TAT protein of HIV can cross cell membranes with remarkable efficiency. By applying ideas from coordination chemistry, soft-condensed-matter physics, and differential geometry, it has been shown that TAT induces saddle-splay curvature in cell membranes, a process that is required for pore formation (see picture of two nonintersecting networks of pores). The results have potential implications for the design of cell-penetrating peptides.

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