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Marc Creus, Anca Pordea, Thibaud Rossel, Alessia Sardo, Christophe Letondor, Anita Ivanova, Isolde LeTrong, Ronald E. Stenkamp and Thomas R. Ward X-Ray Structure and Designed Evolution of an Artificial Transfer Hydrogenase Angewandte Chemie International Edition 47

Version of Record online: 4 JAN 2008 | DOI: 10.1002/anie.200704865

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A structure is worth a thousand words: Guided by the X-ray structure of an S-selective artificial transfer hydrogenase, designed evolution was used to optimize the selectivity of hybrid catalysts. Fine-tuning of the second coordination sphere of the ruthenium center (see picture, orange sphere) by introduction of two point mutations allowed the identification of selective artificial transfer hydrogenases for the reduction of dialkyl ketones.

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