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Aleksandra Velkova, Marianna Tatarek-Nossol, Erika Andreetto and Aphrodite Kapurniotu Exploiting Cross-Amyloid Interactions To Inhibit Protein Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic Angewandte Chemie International Edition 47

Version of Record online: 8 AUG 2008 | DOI: 10.1002/anie.200801499

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Potential aggregate preventer: The designed peptide IAPP-GI inhibits the non-native aggregation of insulin without affecting its function. As the peptide also blocks aggregation of key amyloid peptides that occur in Alzheimer's disease and type II diabetes, it is a promising drug candidate.

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