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Sean W. Smith and Gregory C. Fu Nickel-Catalyzed Negishi Cross-Couplings of Secondary Nucleophiles with Secondary Propargylic Electrophiles at Room Temperature Angewandte Chemie International Edition 47

Version of Record online: 29 OCT 2008 | DOI: 10.1002/anie.200802784

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Mild thing: The first nickel-based catalysts for cross-couplings of secondary organometallic nucleophiles with secondary alkyl electrophiles have been developed. Thus, Negishi reactions proceed under mild conditions (at room temperature with no basic activators) in the presence of NiCl2⋅glyme and a tridentate ligand (see scheme).

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