E-mail a Wiley Online Library Link

Rongjun He, Xisheng Wang, Takuya Hashimoto and Keiji Maruoka Binaphthyl-Modified Quaternary Phosphonium Salts as Chiral Phase-Transfer Catalysts: Asymmetric Amination of β-Keto Esters Angewandte Chemie International Edition 47

Version of Record online: 31 OCT 2008 | DOI: 10.1002/anie.200804140

Thumbnail image of graphical abstract

A reliable phosphonium-based PTC: For the first time a chiral quaternary tetraalkylphosphonium salt has successfully been used as a phase-transfer catalyst (PTC) for asymmetric amination of β-keto esters, in high yield and with high ee (see scheme). Asymmetric amination of a cyclic five-membered β-keto ester is a valuable method for preparing a key intermediate for asymmetric synthesis of aldose reductase inhibitor AS-3201 (Ranirestat).

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field