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Atul Asati, Santimukul Santra, Charalambos Kaittanis, Sudip Nath and J. Manuel Perez Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles Angewandte Chemie International Edition 48

Version of Record online: 7 JAN 2009 | DOI: 10.1002/anie.200805279

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Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).

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