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Axel Schlossbauer, Johann Kecht and Thomas Bein Biotin–Avidin as a Protease-Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica Angewandte Chemie International Edition 48

Article first published online: 23 MAR 2009 | DOI: 10.1002/anie.200805818

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Tell your guests when it's time to go: When avidin caps are attached to biotinylated colloidal mesoporous silica, the four subunits of the protein avidin can each bind to a biotin moiety attached to the surface (see picture). The resulting material is a promising candidate for the design of smart detergents or drug-delivery systems. The caps can be opened to release guest molecules by controlled enzymatic hydrolysis of the protein.

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