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Susan C. Wilkinson, Oscar Lozano, Marie Schuler, Maria C. Pacheco, Roger Salmon and Véronique Gouverneur Electrophilic Fluorocyclization of Allyl Silanes Angewandte Chemie International Edition 48

Version of Record online: 20 AUG 2009 | DOI: 10.1002/anie.200901795

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A refreshing cascade: General fluorocyclization reactions will breathe new life into the use of fluorinated hetero- and carbocycles as pharmaceuticals and agrochemicals. Allyl silanes have now been shown to undergo fluorination–cyclization with N[BOND]F reagents to give cis- and trans-substituted fluorinated heterocycles selectively (see scheme). The correct choice of silyl group was critical to prevent competitive fluorodesilylation.

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