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Zhiqiang Cao, Qiuming Yu, Hong Xue, Gang Cheng and Shaoyi Jiang Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks Angewandte Chemie International Edition 49

Article first published online: 15 APR 2010 | DOI: 10.1002/anie.200907079

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In sharp contrast: Poly(carboxybetaine) (PCB)–poly(lactic-co-glycolic acid) (PLGA) block copolymers were obtained by inclusion of tBu groups onto the PCB monomers. The resulting self-assembled PLGA core/PCB shell nanoparticles have extraordinary stability and a high potential for functionalization because of the COO groups on the PCB shell (see picture; EDC=1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; NHS=N-hydroxysuccinimide).

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