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Prof. Dr. Manfred T. Reetz Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions Angewandte Chemie International Edition 50

Article first published online: 16 AUG 2010 | DOI: 10.1002/anie.201000826

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Evolution in the test tube: The traditional limitations of enzymes as catalysts in organic chemistry or biotechnology—comprising in many cases poor enantioselectivity, limited substrate scope, and insufficient stability—have been eliminated by the techniques of directed evolution. Iterative saturation mutagenesis in particular drives the efficient creation of a new generation of stereoselective biocatalysts which complement chiral synthetic homogeneous catalysts.

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