E-mail a Wiley Online Library Link

Wibke Peters, Sophie Willnow, Mike Duisken, Henning Kleine, Thomas Macherey, Kelly E. Duncan, David W. Litchfield, Bernhard Lüscher and Elmar Weinhold Enzymatic Site-Specific Functionalization of Protein Methyltransferase Substrates with Alkynes for Click Labeling Angewandte Chemie International Edition 49

Version of Record online: 22 JUN 2010 | DOI: 10.1002/anie.201001240

Thumbnail image of graphical abstract

Pass and click: Protein methylation is an important posttranslational modification. Because the methyl group is a poor reporter group, new methods are needed to analyze methyltransferase substrates. A S-adenosyl-L-methionine-based cofactor was synthesized and used for the site-specific functionalization of proteins with alkynes by methyltransferases (first step) and subsequent labeling through CuAAC click chemistry (second step; see scheme).

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field