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Anna Czarna, Barbara Beck, Stuti Srivastava, Grzegorz M. Popowicz, Siglinde Wolf, Yijun Huang, Michal Bista, Tad A. Holak and Alexander Dömling Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists Angewandte Chemie International Edition 49

Article first published online: 23 JUN 2010 | DOI: 10.1002/anie.201001343

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The parallel discovery of multiple scaffolds useful to antagonize the cancer-relevant protein–protein interaction p53/Hdm2 is described. The new method is based on the tightly interwoven interplay of multicomponent reaction chemistry, structural biology, computational chemistry, and high-content NMR-based screening.

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