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Anass Znabet, Eelco Ruijter, Frans J. J. de Kanter, Valentin Köhler, Madeleine Helliwell, Nicholas J. Turner and Romano V. A. Orru Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions Angewandte Chemie International Edition 49

Version of Record online: 23 JUN 2010 | DOI: 10.1002/anie.201001592

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Time and pep-tide wait for no man: Optically pure 3,4-disubstituted 1-pyrrolines, generated from the corresponding meso-pyrrolidines by biocatalytic desymmetrization (MAO-N=monoamine oxidase N), react with carboxylic acids and isocyanides in a highly diastereoselective Ugi-type multicomponent reaction to give substituted prolyl peptides of high pharmaceutical relevance.

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