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Yongzheng Chen, Weng Lin Tang, Jie Mou and Zhi Li High-Throughput Method for Determining the Enantioselectivity of Enzyme-Catalyzed Hydroxylations Based on Mass Spectrometry Angewandte Chemie International Edition 49

Version of Record online: 22 JUN 2010 | DOI: 10.1002/anie.201001772

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Up to speed: An accurate, sensitive, high-throughput, and simple method for measuring the product ee value of enzyme-catalyzed hydroxylations (see scheme) is based on the use of enantiopure or enantioenriched deuterated substrates and mass spectrometric detection.

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