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Estela Climent, Prof. Ramón Martínez-Máñez, Dr. Félix Sancenón, Dr. María D. Marcos, Dr. Juan Soto, Prof. Angel Maquieira and Prof. Pedro Amorós Controlled Delivery Using Oligonucleotide-Capped Mesoporous Silica Nanoparticles Angewandte Chemie International Edition 49

Article first published online: 24 AUG 2010 | DOI: 10.1002/anie.201001847

Thumbnail image of graphical abstract

Caps off! A single-stranded oligonucleotide capped the pores on the surface of a silica mesoporous support, which contained an entrapped guest. In the presence of a complementary strand, the “molecular lock” on the delivery vehicle was opened and the entrapped guests were selectively released.

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