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Martin Münzel, Daniel Globisch, Tobias Brückl, Mirko Wagner, Veronika Welzmiller, Stylianos Michalakis, Markus Müller, Martin Biel and Thomas Carell Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain Angewandte Chemie International Edition 49

Version of Record online: 25 JUN 2010 | DOI: 10.1002/anie.201002033

Thumbnail image of graphical abstract

Mind over matter: LC-MS has allowed the amount of the post-replicatively formed DNA base 5-hydroxymethylcytosine (see picture; left) to be quantified in brain tissue. The nucleoside is most abundant in areas that are associated with higher cognitive functions, and its content in mouse hippocampi seems to increase with age. The new method enables hydroxymethylcytosine to be quantified with unprecedented accuracy.

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