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Conrad Kunick and Ingo Ott Metal Complexes as Protein Kinase Inhibitors Angewandte Chemie International Edition 49

Article first published online: 29 JUN 2010 | DOI: 10.1002/anie.201002062

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Angiogenesis inhibition: Metal complexes are often overlooked in the development of new drugs. However, rationally designed iridium complexes with bidentate pyridocarbazole ligands have been found to act as selective protein kinase inhibitors. Experiments in zebrafish embryos revealed impressive anti-angiogenic effects for this type of metallodrug. (Picture: tumor-induced angiogenesis in a zebrafish embryo; red: transplanted tumor cells, green: blood vessels).

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