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John Podtetenieff, Andreas Taglieber, Eckhard Bill, Edward J. Reijerse and Manfred T. Reetz An Artificial Metalloenzyme: Creation of a Designed Copper Binding Site in a Thermostable Protein Angewandte Chemie International Edition 49

Article first published online: 22 JUN 2010 | DOI: 10.1002/anie.201002106

Thumbnail image of graphical abstract

Guided by nature: A designed binding site comprising the His/His/Asp motif for CuII complexation has been constructed in a robust protein by site-specific mutagenesis (see picture). The artificial metalloenzyme catalyzes an enantioselective Diels–Alder reaction.

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