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Bartlomiej Kowalczyk, David A. Walker, Siowling Soh and Bartosz A. Grzybowski Nanoparticle Supracrystals and Layered Supracrystals as Chemical Amplifiers Angewandte Chemie International Edition 49

Version of Record online: 13 JUL 2010 | DOI: 10.1002/anie.201002295

Thumbnail image of graphical abstract

Seeing is believing: Nanoparticle crystals and core–shell crystals detect and amplify the presence of chemical and enzymatic analytes. These crystals are made insoluble in water by cross-linking their surface with dithiols incorporating analyte-specific groups. Upon addition of an analyte, these groups are cut, and the “punctured” crystals liberate millions of individual, brightly colored NPs (see picture).

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