Harriet Teare, Dr. Edward G. Robins, Anna Kirjavainen, Sarita Forsback, Prof. Graham Sandford, Prof. Olof Solin, Dr. Sajinder K. Luthra and Prof. Véronique Gouverneur Radiosynthesis and Evaluation of [18F]Selectfluor bis(triflate) Angewandte Chemie International Edition 49
Selectfluor, one of the most reactive and commonly used electrophilic fluorinating N–F reagents, has been radiolabeled with 18F. The resulting new [18F]-labeled N–F reagent is safe, nontoxic, and easy to handle. The combined use of [18F]Selectfluor bis(triflate) and AgOTf allows for the preparation of electron-rich 18F-aromatic compounds through a simple “shake and mix” protocol at room temperature (see scheme; SA=specific activtiy).
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