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Chao Wang, Qishui Chen, Prof. Zhiqiang Wang and Prof. Xi Zhang An Enzyme-Responsive Polymeric Superamphiphile Angewandte Chemie International Edition 49

Article first published online: 30 SEP 2010 | DOI: 10.1002/anie.201004253

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Responding to treatment: A superamphiphile is formed between a double-hydrophilic polymer (methoxy-poly(ethylene glycol)-block-poly(L-lysine hydrochloride)) and a natural enzyme-responsive molecule (adenosine 5′-triphosphate). The superamphiphile self-assembles into spherical aggregates, which, upon addition of enzymes, disassemble and release loaded molecules (see picture).

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