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Dr. Zhong Luo, Prof. Kaiyong Cai, Dr. Yan Hu, Dr. Li Zhao, Dr. Peng Liu, Lin Duan and Dr. Weihu Yang Mesoporous Silica Nanoparticles End-Capped with Collagen: Redox-Responsive Nanoreservoirs for Targeted Drug Delivery Angewandte Chemie International Edition 50

Article first published online: 9 DEC 2010 | DOI: 10.1002/anie.201005061

Thumbnail image of graphical abstract

If the cap fits: Attachment of collagen (Col) to silica nanoparticles (MSN) by a disulfide linker, followed by introduction of lactobionic acid (LA, a cell-specific targeting moiety), results in a redox-responsive system for cell-specific intracellular drug delivery and efficient endocytosis (see picture). Controlled release of a model drug (fluorescein isothiocyanate, FITC) was achieved by cleavage of the disufide bonds.

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