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Dr. Kathrin Breuker, Sven Brüschweiler and Priv.-Doz. Dr. Martin Tollinger Electrostatic Stabilization of a Native Protein Structure in the Gas Phase Angewandte Chemie International Edition 50

Article first published online: 9 NOV 2010 | DOI: 10.1002/anie.201005112

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One, two, three, whee! After transfer into the gas phase, the three-helix bundle protein KIX is sufficiently stabilized by electrostatic interactions to compensate for the loss of hydrophobic bonding. It thus retains its global fold on a timescale of more than 4 s.

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