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Dr. Axel Schlossbauer, Christian Dohmen, Dr. David Schaffert, Prof. Dr. Ernst Wagner and Prof. Dr. Thomas Bein pH-Responsive Release of Acetal-Linked Melittin from SBA-15 Mesoporous Silica Angewandte Chemie International Edition 50

Version of Record online: 17 JUN 2011 | DOI: 10.1002/anie.201005120

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Free to go: A pH-labile immobilization of the melittin peptide with acetal linkers in the pore system of a SBA-15 host allows release of the peptide upon decrease of the pH value from 7.4 to 5.5. Such a release is shown by melittin-induced lysis of mouse erythrocytes. The method could be used to prepare new silica-based peptide delivery systems for targeted cancer therapy.

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