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Dr. Zhongping Tan, Dr. Shiying Shang and Prof. Samuel J. Danishefsky Insights into the Finer Issues of Native Chemical Ligation: An Approach to Cascade Ligations Angewandte Chemie International Edition 49

Version of Record online: 4 NOV 2010 | DOI: 10.1002/anie.201005513

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Maximizing by minimizing: An efficient and broadly useful two-step ligation protocol was developed. Important mechanistic issues of ligation were probed from competition studies on the formation of diastereomeric ligation products. This study provides a valuable approach to facilitate polypeptide synthesis by minimizing protecting group manipulations and intermediate isolations.

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